Going turbo will be easiest way to get 200-250hp out of a D16. You WILL want forged Rods at that power level otherwise your engine will be a ticking timebomb waiting for the OEM Rod bolts or your OEM rods to fail.
Turbo d16's are cheap(relatively speaking) and easy to work on. D parts are also a good deal cheaper than B and H parts.
Another thing to remember even when the engine is built up. At 200-250hp with out an LSD Transmission you will have a VERY hard time catching traction, ESPECIALLY if you live in a northern US states. Even with an LSD unless you have warmer weather it will still be hard to get traction on street tires. In Washington slicks are not Road legal.
Seeing my friends with high hp hondas fail to put down their power most of the year was one of the factors for me buying my Subaru WRX Wagon. Its AWD lets me put my power down all the time including when its pouring down rain. Having over 250-300hp in a FWD honda, especially
without LSD, will be very unsafe in slick conditions.
If its often cold or wet where you live, it might be worth looking to do an AWD setup or at the very least, get an LSD put into your transmission. When its open getting better synchros and stronger gears are a good idea.
This is something most people don't think of when they build up a car. Making power is so easy when you compare it to putting that power down to the ground. Good Luck.
Another idea if you want to stay with lower power would be to put in different gears.
M Factory makes different gear sets and final drives.
My JDM b20 with a LS transmission will be slower then a D16z6 with an EX transmission. However bolt up a b16 transmission and the shorter gear ratios let me beat up on GSR swaps. It will smoke b16's like breakfast. Point of the story is that gear ratios effect how fast your car is. Going to a shorter gear ratio will allow your car will be faster without making more power. Just another thing to consider when building up your car.